contributions on Quantifying Cancer Progression with Conjunctive Bayesian Networks

Notes

Beerenwinkel (one of the authors) previously put some assumptions and followed them when modelling the accumulative evolutionary process. Such assumptions are:

1. Substitutions do not occur independently. There are preferred evolutionary pathways in which mutations are fixed

2. The fixation mutations into the population is definite. This means that substitutions are non-reversible

3. At each time point, the virus population is dominated by a single strain and clones are independent and (sometimes erroneous) copies of this genotype

Improvements

As mentioned in the paper, an improvement on the proposed model would be to use different parameters [math]\displaystyle{ \varepsilon^+ }[/math] and [math]\displaystyle{ \varepsilon^- }[/math] for false positives and false negatives in the error model. Beerenwinkel and Drton have developed this idea.

LEt

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